Pig-a In Vivo Gene Mutation Assay Database

Background

This database was compiled as a joint effort of the Genetic Toxicology Technical Committee (GTTC) of the ILSI Health and Environmental Sciences Institute (HESI) and the Center of Excellence in Regulatory Science and Innovation at the University of Maryland (M-CERSI) and is updated occasionally as new data are made available. 

The data primarily come from published work; however, in many cases, the investigators have supplied primary data and experimental details that cannot be found in the open literature.  Information from unpublished studies not listed in the database may be available upon request, and with agreement of the investigators. Where complete primary data and details were not available, the information that could be accessed is listed, and where values were estimated from graphs, this is indicated in the database. The main objective of the database is to provide the necessary information for conducting a Retrospective Performance Analysis of the Pig-a gene mutation assay as described in Organisation for Economic Co-operation and Development (OECD) Guidance Document #34; however, it is hoped that it will be a useful resource for other applications as well.

How to Use the Database

  • The database primarily contains results of Pig-a gene mutation assays conducted in rats and mice.  
  • Files are arranged below in alphabetical order, using descriptive titles (lab, agent, treatment duration, etc).
  • Search boxes are provided that will limit the list of files to those with data from a specific test article, treatment protocol, species, sex, etc.
  • Clicking on a file name will download an Excel spreadsheet containing detailed information from the study described in the file.
  • The spreadsheet can be saved to your computer or the information in the file copied and pasted into a secondary application.

Contact

For additional information about the database, and assistance in adding additional entries, contact Lea Patrice McDaniel.

Database










Test Article(s)CAS # (#s)SpeciesSexVehicleRouteTreatment RegimeCells AssayedImmunomagnetic SeparationData File Name
Benzo(a)pyrene 50.32.8 Mouse Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron BaP 3day Mouse Study
Chlorambucil 305.03.3 Rat Male Other PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Chlorambucil 3day Rat Study
Chlorambucil 305.03.3 Rat Male Other PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Chlorambucil 28day2 Rat Study
Cisplatin 15663.27.1 Rat Male Other IP 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Cisplatin 28d Rat Study PR130702
Cyclophosphamide Monohydrate 6055.19.2 Rat Male Water PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Cyclophosphamide 3d Rat Study PR110802
Pyrene, Benzo(a)pyrene 129.00.0, 50.32.8 Mouse Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Pyrene BaP 3day Mouse Study
Radiation (blank) Rat Male (blank) Other 1/dayX3days Total RBCs No NCTR X-rays rat study
Water, 1,3 Propane Sultone, Thiotepa, Ethyl Carbamate 7732.18.5, 1120.71.4, 52.24.4, 51.79.6 Rat Male, Female, Both Water PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron 1 3 propane sultone ethylcarbamate thiotepa water 3day rat Study
Cyclophosphamide Monohydrate 6055.19.2 Rat Male Water PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Cyclophosphamide 28d Rat Study PR110712
Azathoprine 446.86.6 Rat Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Chlorambucil 3day Rat Study
Azathoprine 446.86.6 Rat Male Oil PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Azathioprine 28day Rat Study
Diethylnitrosamine 55.18.5 Rat Male Water PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Diethylnitrosamine 28d Rat Study PR130910
Radiation (blank) Rat Female (blank) Other Other RETs, Total RBCs, Both RETs and Total RBCs Yes
AZT 30516.87.1 Mouse Male, Female, Both Water PO Other Total RBCs No NCTR AZT mouse study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male, Female, Both PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron ENU MF 3day rat study
N-Ethyl-N-Nitrosourea 759.73.9 Mouse Male PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron ENU 3day Mouse Study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male, Female, Both PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron ENU MF Older age 3day Rat Study
N-Nitroso-N-Methylurea 684.93.5 Rat Male PBS PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No GSK MNU 28day rat study
4-chloro-1,2-diaminobenzene, N-Ethyl-N-Nitrosourea 95.83.0, 759.73.9 Rat Male Oil, PBS PO 1/dayX28days, 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes GSK 4-chloro-12-diaminobenzene 28day rat study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes PBR ENU 3d rat study_TEH_180
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes PBR ENU 28d rat study_TEH_181
3,5 diflurophenylboronic acid, N-Ethyl-N-Nitrosourea  156545.07.2, 759.73.9 Rat Male Other, PBS PO 1/dayX28days, 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes GSK 3 5 DFPB acid 28day rat study
4-Nitroquinoline-N-Oxide 76082.65.0 Rat Male Other PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No AbbVie 4NQO 28day rat study
Methyl Carbamate, Ethyl Carbamate 598.55.0, 51.79.6 Mouse Male Water PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron MethylCarbamate urethane 3day Mouse Study
Melphalan 148.82.3 Rat Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Melphalan 3day Rat Study
Melphalan 148.82.3 Rat Male Oil PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Melphalan 28day Rat Study
Melphalan 148.82.3 Rat Male Oil PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Melphalan 28day2 Rat Study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes ITR Canada ENU 3day rat study
Furan 110.00.9 Rat Male Oil PO Other Total RBCs No NCTR Furan rat study
Sodium Chloride, N-Ethyl-N-Nitrosourea 7647.14.5, 759.73.9 Rat Male Water PO 1/dayX28days, 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron_NaCl_28d_Rat Study PR120417_v2
Sodium Chloride, N-Ethyl-N-Nitrosourea 7647.14.5, 759.73.9 Rat Male Water PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron_NaCl_3D_Rat Study PR120410
Etoposide 33419.42.0 Rat Male Other Other 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes, No Astellas Etoposide single dose rat study
Methylphenidate hydrochloride 113.45.1 Rat Male Water Other Other Total RBCs No NCTR MPH 28d rat study
Glycidyl methacrylate 106.91.2 Rat Male Oil PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes NCTR Glycidyl methacrylate 28day rat study
Aristolochic Acid 313.67.7 Rat Male PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes NCTR Aristolochic Acid 3day rat study
Aristolochic Acid 313.67.7 Rat Male PBS PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes NCTR Aristolochic Acid 28day rat study
Hydroxyurea, N-Ethyl-N-Nitrosourea  127.07.1, 759.73.9 Rat Male Water, PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Hydroxyurea 3d Rat Study PR120306
Hydroxyurea, N-Ethyl-N-Nitrosourea  127.07.1, 759.73.9 Rat Male Water, PBS PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Hydroxyurea 28d Rat Study PR120313
Ethyl Carbamate 51.79.6 Mouse Male Water PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron EthylCarb 3day Mouse Study
4-nitroquinoline-1-oxide 56.57.5 Rat Male Other PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No Covance 4NQO 28day rat study
Dichloromethane 75.09.2 Mouse Male (blank) Other Other Total RBCs No JNIOSH Dichloromethane 42day mouse study
1,2-dichloropropane 78.87.5 Mouse Male (blank) Other Other Total RBCs No JNIOSH 12-Dichloropropane 42days mouse study
Methyl methanesulfonate 66.27.3 Rat Male Water PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron MMS 3day Rat Study
Methyl methanesulfonate 66.27.3 Rat Male Water PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron MMS 28day Rat Study
Acrylamide 79.06.1 Rat Male Water PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes NCTR Acrylamide 28d rat study
1,3PropaneSultone 1120.71.4 Rat Male Water PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Propane Sultone 3day Rat Study
1,3PropaneSultone 1120.71.4 Rat Male Water PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Propane Sultone 28day Rat Study
1,3PropaneSultone 1120.71.4 Rat Male Water PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Propane Sultone 28day2 Rat Study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs No BMS ENU 3day rat study
N-Methyl-N-Nitrosourea 684.95.3 Rat Male PBS PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No BMS MNU-1 28day rat study
N-Methyl-N-Nitrosourea 684.95.3 Rat Male PBS PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes BMS MNU-3 28day rat study
Acetaminophen, N-Ethyl-N-Nitrosourea  103.90.2, 759.73.9 Rat Male Other, PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes BoZo Research Center acetaminophen ENU 1day rat study
Cisplatin, N-Ethyl-N-Nitrosourea 15663.27.1, 759.73.9 Rat Male Other, PBS Other, PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes BoZo Research Center Cisplatin ENU 1day rat study
ethyl methanesulfonate, N-Ethyl-N-Nitrosourea 62.50.0, 759.73.9 Rat Male Water, PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes DaiichiSankyo EMS 1day rat study
isopropyl methanesulfonate, N-Ethyl-N-Nitrosourea 926.06.7, 759.73.9 Rat Male PBS IP 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes DaiichiSankyo iPMS 1day rat study
Cyclophosphamide 50.18.0 Rat Male Water PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Teijin Cyclophosphamide 1day rat study
4-nitroquinoline-1–oxide 56.57.5 Rat Male Other PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes NCDSER 4NQO 28day rat study
5-fluorouracil 51.21.8 Rat Male Water PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes NCDSER 5-fluorouracil 3day rat study
Isopropyl methanesulfonate 926.06.7 Rat Male Water IP 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Pfizer IPMS 28 day rat Study
Benzo(a)pyrene 50.32.8 Rat Male Oil PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No NCTR Benzo(a)pyrene 28day rat study
Cisplatin 15663.27.1 Rat Male Other IV 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes NCTR Cisplatin 3day rat study
Cisplatin 15663.27.1 Rat Male Other IV 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes NCTR Cisplatin early MutaFlow rat study
Cisplatin 15663.27.1 Rat Male Other IV 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes NCTR Cisplatin PIGRET rat study
Cyclophosphamide 50.18.0 Rat Male PBS IP 1/dayX1day Total RBCs No NCTR Cyclophosphamide 1day rat study
Ethyl methanesulfonate 62.50.0 Rat Male PBS PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes NCTR EMS HT 28Day rat study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No NCTR ENU Basic Method 28Day rat study
N-Ethyl-N-Nitrosourea 759.73.9 Mouse Male, Female, Both PBS PO 1/dayX1day Total RBCs No NCTR ENU mouse study
Pyrene, Benzo(a)pyrene 129.00.0, 50.32.8 Rat Male Oil PO Other RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Pyrene 3d Rat Study PR111108
Pyrene, Benzo(a)pyrene 129.00.0, 50.32.8 Rat Male Oil PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Pyrene 28d Rat Study PR111011
Thiotepa 52.24.4 Rat Male Water PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Thiotepa 3d Rat Study PR110503
Thiotepa 52.24.4 Rat Male Water PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Thiotepa 28d Rat Study PR110412
Thiotepa 52.24.4 Rat Male Water PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron Thiotepa 28d Rat Study PR130416
2-Acetylaminofluorene 53.96.3 Rat Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron_2AAF_3d_Rat Study PR110517
2-Acetylaminofluorene 53.96.3 Rat Male Oil PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron_2AAF_28d_Rat Study PR110510_v2
o-Anthranilic acid, N-Ethyl-N-Nitrosourea 118.92.3, 759.73.9 Rat Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron_Anthranilic acid_3d_Rat Study PR110628
o-Anthranilic acid, N-Ethyl-N-Nitrosourea 118.92.3, 759.73.9 Rat Male Oil PO 1/dayX28days, 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron_Anthranilic acid_28d_Rat Study PR110607
Sulfisoxazole, N-Ethyl-N-Nitrosourea 127.69.5, 759.73.9 Rat Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron_Sulfisoxazole_3d_Rat_Study PR111004
Sulfisoxazole, N-Ethyl-N-Nitrosourea 127.69.5, 759.73.9 Rat Male Oil PO 1/dayX28days, 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Litron_Sulfisoxazole_28d_Rat_Study PR110913
N-Ethyl-N-Nitrosourea 759.73.9 Mouse
Male PBS IP Other RETs, Total RBCs, Both RETs and Total RBCs No NCTR ENU mouse study
Caffeic Acid 331.39.5 Rat Male
Other
PO
1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Covance Caffeic Acid 3day rat studyCovance Caffeic Acid 3day rat study
Melamine 108.78.1 Rat Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes NCDSER Melamine 3day rat study
Fullerene, N-Ethyl-N-Nitrosourea 99685.96.8, 759.73.9 Mouse Male Other, PBS IP, PO 1/dayX1day Total RBCs No NIHS Fullerene 1day mouse study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Teijin ENU 1day rat study
7,12-Dimethyl-benz[a]anthracene 57.97.6 Rat Male Oil PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Teijin DMBA 1day rat study
4-nitroquinoline-1–oxide 56.57.5 Rat Male Other PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Teijin 4NQO 1day rat study
N-Ethyl-N-Nitrosourea 759.73.9 Mouse Male PBS IP 1/dayX1day Total RBCs No Faculty of Public Health Shanghai Jiao Tong University School of Medicine 3R4Fcigarettes mouse study
Benzo(a)pyrene 50.32.8 Mouse Male, Female, Both Oil IP Other Total RBCs No Faculty of Public Health Shanghai Jiao Tong University School of Medicine BaP mouse study
3R4F Reference Cigarette (0.73mg nicotine) (blank) Mouse Male (blank) Other Other Total RBCs No Faculty of Public Health Shanghai Jiao Tong University School of Medicine 3R4Fcigarettes mouse study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs No Roche ENU 3day rat study
Methyl methanesulfonate 66.27.3 Rat Male Water PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Roche MMS 28day rat study
Acrylamide, N-Ethyl-N-Nitrosourea 79.06.1, 759.73.9 Rat Male Water, PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes NIHS Acrylamide 1day rat study
olive oil, 3-monochloropropane-1,2-diol, 3-MCPD palmitate diester, 3-MCPD palmitate monoester, 3-MCPD oleate diester 8001.25.0, 96.24.2, 51930.97.3, 30557.04.1, 69161.73.5 Rat Male Oil PO Other Total RBCs No NIHS 3-MCPD 20times rat study
N-Ethyl-N-Nitrosourea, 4-nitroquinoline-1–oxide, Benzo(a)pyrene 759.73.9, 56.57.5, 50.32.8 Mouse Male PBS, Oil PO 1/dayX1day Total RBCs No NIHS 3-MCPD 20times rat study
Benzo(a)pyrene, corn oil 50.32.8, 8001.30.7 Mouse Male Oil IP 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs No NIPH BaP 3day mouse study
Radiation (blank) Mouse Male (blank) Other 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs No NIPH Japan xray mouse study
3R4F Reference Cigarette (0.73mg nicotine) (blank) Rat Male, Female, Both (blank) Other Other RETs, Total RBCs, Both RETs and Total RBCs Yes BAT 3R4Fcigarette inhal rat study
Radiation (blank) Mouse Male (blank) Other 1/dayX1day, Other RETs, Total RBCs, Both RETs and Total RBCs No NIPH Japan xray mouse study
7,12-Dimethyl-benz[a]anthracene 57.97.6 Rat Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes Janssen DMBA 3day rat study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Female PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes ENEA ENU 3day rat study
CeO2 NM-212, BaSO4 NM-220 (blank) Rat Female (blank) Other Other RETs, Total RBCs, Both RETs and Total RBCs Yes ENEA CeO2 BaSO4 nano inhalation rat study
2-Butoxyethanol 111.76.2 Rat Male Water PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Pfizer 2-butoxyethanol 1day rat study
2-Butoxyethanol 111.76.2 Rat Male Water PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs Yes Pfizer 2-butoxyethanol 28day ray study
Isopropyl methanesulfonate 926.06.7 Rat Male Water IP 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Pfizer IPMS 1day Rat Study
Benzo(a)pyrene 50-32-8 Mouse Male Oil PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No Health Canada BaP 28day Mouse Study
Benzo(a)pyrene, N-Ethyl-N-Nitrosourea 50-32-8, 759.73.9 Rat Male Oil, PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Taisho pharma BaP 1day rat study
azathioprine, N-Ethyl-N-Nitrosourea 446.86.6,  759.73.9 Rat Male Oil, PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Takeda Pharma azathioprine 1day Rat study
Pyrene, N-Ethyl-N-Nitrosourea 129.00.0, 759.73.9 Rat Male Oil, PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Takeda Pharma pyrene 1day rat study
Isopropyl p-toluenesulfonate, N-Ethyl-N-Nitrosourea 2307-69-9, 759.73.9 Rat Male Oil, PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Teijin IPTS 1day rat study
Ethyl Carbamate, N-Ethyl-N-Nitrosourea 51.79.6, 759.73.9 Rat Male Water, PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Yakult Honsha Urethane ENU 1day rat study
Chlorambucil,  N-Ethyl-N-Nitrosourea 305-03-3, 759.73.9 Rat Male Other, PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Toray Industries chlorambucil ENU 1day rat study
Acrylamide, N-Ethyl-N-Nitrosourea 79-06-1, 759.73.9 Rat Male Other Other Other RETs, Total RBCs, Both RETs and Total RBCs Yes  ILS Acrylamide ENU rat study
Acrylamide, N-Ethyl-N-Nitrosourea 79-06-1, 759.73.9 Mouse Male Water Other Other RETs, Total RBCs, Both RETs and Total RBCs Yes  ILS Acrylamide ENU mouse study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Female PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes Teijin ENU 1day female rat study
Ethylmethane sulfonate 62-50-0 Rat Male PBS PO 1/dayX1day Total RBCs No Teijin EMS 1day rat study
1,3PropaneSultone 1120.71.4 Rat Male Water PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes LSI Medience 1 3 propane sultone 1day rat study
2-acetylaminofluorene 53.96.3 Rat Male Oil PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes  LSI Medience 2AAF 1day rat study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs No Litron ENU 3day rat study PR090330
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs No Litron ENU 3day rat Study PR090202
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No Litron ENU 28day rat Study PR090706
Benzo(a)pyrene 50-32-8 Rat Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs No Litron BAP 3day rat Study PR090316
Benzo(a)pyrene 50-32-8 Rat Male Oil PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No Litron BAP 28days rat Study PR090813
4-Nitroquinoline-1-oxide 56.57.5 Rat Male Other PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs No Litron 4NQO 3day rat Study PR090309
4-Nitroquinoline-1-oxide 56.57.5 Rat Male Other PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No Litron 4NQO 28day rat Study PR090914
7,12-Dimethylbenz(a)anthracene 57.97.6 Rat Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs No Litron DMBA 3day rat Study PR090406
7,12-Dimethylbenz(a)anthracene 57.97.6 Rat Male Oil PO 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs No Litron DMBA 3 day rat Study PR090209
7,12-Dimethylbenz(a)anthracene 57.97.6 Rat Male Oil PO 1/dayX28days RETs, Total RBCs, Both RETs and Total RBCs No

Litron DMBA 28day rat Study PR090810

Procarbazine 366.70.1 Rat Male Other IP 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs Yes  Covance Procarbazine 3day rat study
PVP Coated Ag-NPs (5 nm) (blank) Mouse Male Water IV 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs No  NCTR Silver NPs 1dose mouse study
TiO2- NPs (10 nM) (blank) Mouse Male PBS IV 1/dayX3days RETs, Total RBCs, Both RETs and Total RBCs No  NCTR TiO2 NPs 3day mouse study
N-Ethyl-N-Nitrosourea 759.73.9 Rat Male PBS PO 1/dayX1day RETs, Total RBCs, Both RETs and Total RBCs Yes  NIHS ENU 1day gptRat study