Publications & Presentations

Faculty, staff, and students in the Mass Spectrometry Center at the University of Maryland School of Pharmacy have been published in numerous peer-reviewed publications, and have delivered presentations at both national and international conferences.


Publications

2016 

Williams CL, Neu HM, Gilbreath JJ, Michel SL, Aurawski DV, Merrell DS. Characterization of Copper Resistance in Acinetobacter bauminnii. Appl Environ Microbiol. 2016 Aug 12. pii: AEM.01813-16. PMID: 27520808

Deredge D, Li J, Johnson KA, Wintrode PL. Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase. J Biol Chem2016 Mar 22. pii: jbc.M115.708370. PMID: 27006396

2015 

Alonso S, Su M, Jones JW, Ganguly S, Kane MA, Jones RJ, Ghiaur G. Human Bone Marrow Niche Chemoprotection Mediated by Cytochrome P450 Enzymes. Oncotarget. 2015 Jun 20;6(17):14905-12. PMID: 25915157. PMCID: PMC4558124

Best MW, Wu J, Pauli SA, Kane MA, Pierzchalski K, Session DR, Woods DC, Shang W, Taylor RN, Sidell N. A role for retinoids in human oocyte fertilization: Regulation of connexin 43 by retinoic acid in cumulus granulosa cells. Mol Hum Reprod. 2015 Jun;21(6):527-34. doi: 10.1093/molehr/gav017. Epub 2015 Apr 15. PMID: 25877907

Byrareddy SN, Sidell N, Zhao C, Dunbar P, Little D, Yang GX, Pierzchalski K, Kane MA, Mayne A, Arthos J, Cicala C, Song B, Soares MA, Villinger F, Ansari A. Species-Specific Differences in the Expression and Regulation of Alpha 4 Beta7 (α4β7) integrin in Various Non-Human Primates. Journal of Immunology. 2015 Jun 15;194(12):5968-79. doi: 10.4049/jimmunol.1402866. Epub 2015 May 6. PMID: 25948815

Carter CL, Jones JW, Barrow K, Kieta K, Taylor-Howell C, Kearney S, Smith CP, Gibbs A, Farese AM, MacVittie TJ, Kane MA. A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development. Health Phys. 2015 Nov;109(5):466-78. doi: 10.1097/HP.0000000000000353. PMID: 26425906

Jones JW, Bennett A, Carter CL, Tudor G, Hankey KG, Farese AM, Booth C, MacVittie TJ, Kane MA. Citrulline as a Biomarker in the Non-human Primate Total- and Partial-body Irradiation Models: Correlation of Circulating Citrulline to Acute and Prolonged Gastrointestinal Injury. Health Phys. 2015 Nov;109(5):440-51. doi: 10.1097/HP.0000000000000347. PMID: 26425904

Jones JW, Pierzchalski K, Yu J, Kane MA.The use of fast HPLC multiplexing MRM3 for endogenous retinoic acid quantification in complex matrices.Anal Chem. 2015 Mar 17;87(6):3222-30. doi: 10.1021/ac504597q. Epub 2015 Mar 9. PMID: 25704261

Jones JW, Thompson CJ, Carter CL, Kane MA. Electron-induced dissociation (EID) for structure characterization of glycerophosphatidylcholine: determination of double-bond positions and localization of acyl chains. J Mass Spectrom. 2015 Dec;50(12):ii. doi: 10.1002/jms.3499. PMID: 26634981

Jones JW, Tudor G, Li F, Tong Y, Katz B, Farese AM, MacVittie TJ, Booth C, Kane MA. Citrulline as a Biomarker in the Murine Total-Body Irradiation Model: Correlation of Circulating and Tissue Citrulline to Small Intestine Epithelial Histopathology. Health Phys. 2015 Nov;109(5):452-65. doi: 10.1097/HP.0000000000000346. PMID: 26425905

Lupton, C.J., Steer, D.L., Wintrode, P.L., Bottomley, S.P., Hughes, V.A. and Ellison, A.M. (2015) Enhanced Molecular Mobility of Ordinarily Structured Regions Drives Polyglutamine Disease. J. Biol. Chem., 290 24190-24200. DOI:10.1074/jbc.M115.659532. PMID: 26260925

Nguyen AT, Jones JW, Ruge MA, Kane MA, Oglesby-Sherrouse AG. Iron Depletion Enhances Production of Antimicrobials by Pseudomonas aeruginosa. J Bacteriol. 2015 Jul;197(14):2265-75. doi: 10.1128/JB.00072-15. Epub 2015 Apr 27. PMID: 25917911. PMCID: PMC4524187

Reinhart AA, Powell DA, Nguyen AT, O’Neill M, Djapgne L, Wilks A, Ernst RK, Oglesby-Sherrouse AG. (2015) The prrF-encoded small regulatory RNAs are required for iron homeostasis and virulence of Pseudomonas aeruginosa. Infection and Immunity 83(3):863-875. PMID: 25510881

Su M, Alonso-Martinez S, Jones JW, Yu J, Kane MA, Jones RJ, Ghiaur G.  All-Trans Retinoic Acid Activity in Human Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment. PLoS One. 2015 Jun 5;10(6):e0127790. doi: 10.1371/journal.pone.0127790. eCollection 2015. PMID: 26047326. PMCID: PMC4457893

Taylor RN, Kane MA, Sidell N. Pathogenesis of Endometriosis: Roles of Retinoids and Inflammatory Pathways. Semin Reprod Med. 2015 Jul;33(4):246-56. doi: 10.1055/s-0035-1554920. Epub 2015 Jul 1. PMID: 26132929

Ting TY, Jiang W, Lionberger R, Wong J, Jones JW, Kane MA, Krumholz A, Temple R, Polli JE. Generic lamotrigine versus brand-name Lamictal bioequivalence in patients with epilepsy: A field test of the FDA bioequivalence standard. Epilepsia. 2015 Sep;56(9):1415-24. doi: 10.1111/epi.13095. Epub 2015 Jul 23. PMID: 26201987 

Vaithianathan S, Haidar SH, Zhang X, Jiang W, Avon C, Dowling TC, Shao C, Kane M, Hoag SW, Flasar MH, Ting TY, Polli JE. Effect of Common Excipients on the Oral Drug Absorption of Biopharmaceutics Classification System Class 3 Drugs Cimetidine and Acyclovir. J Pharm Sci. 2015 Sep 16. doi: 10.1002/jps.24643. PMID: 26375604

Vaithianathan S, Raman S, Jiang W, Ting TY, Kane MA, Polli JE. Biopharmaceutic Risk Assessment of Brand and Generic Lamotrigine Tablets. Mol Pharm. 2015 Jul 6;12(7):2436-43. doi: 10.1021/acs.molpharmaceut.5b00154. Epub 2015 Jun 2. PMID: 26001027

Wehman B, Dawood M, Ghoreishi M, Cheema F, Jones JW, Kane MA, Ward CW, Gammie JS. Surgical Management of Caseous Calcification of the Mitral Annulus. Ann Thorac Surg. 2015 Jun;99(6):2231-3. doi: 10.1016/j.athoracsur.2015.02.106. PMID: 26046892

White, M., Khan, M.M., Deredge, D., Ross, C.R., Quintyn, R., Zucconi, B.E., Wysocki, V.H., Wintrode, P.L., Wilson, G.M. and Garcin, E.D. (2015) A dimer interface mutation in glyceraldehyde-3-phosphate dehydrogenase regulates its binding to AU-rich RNA. J. Biol. Chem., 290 1770-1785. DOI:10.1074/jbc.M114.618165. PMID: 25681510

2014 

Carter CL, MacVittie TJ, Kane MA. MALDI-MSI: Biomarker Discovery for Radiation Exposures. Three Encyclopedia, Systems Biology. Three Encyclopedia, Systems Biology, 2014 (March 24). https://three.jsc.nasa.gov

Gutierrez-Mazariegos J, Kumar Nadendla E, Lima D, Pierzchalski K, Jones JW, Kane M, Nishikawa JI, Hiromori Y, Nakanishi T, Santos MM, Castro LF, Bourguet W, Schubert M, Laudet V. A mollusk Retinoic Acid Receptor (RAR) ortholog sheds light on the evolution of ligand binding. Endocrinology. 2014 Aug 13:en20141181. [Epub ahead of print]. PMID: 25116705. PMCID: PMC4197984

Hughes, V.A., Meklemburg, R., Bottomley, S.P. and Wintrode P.L. (2014) The Z mutation alters the global structural dynamics of alpha-1 antitrypsin. PLoS ONE 9(9):e102617. doi:10.1371/journal.pone.0102617. PMID: 25181470

Jones JW, Scott AJ, Tudor G, Xu PT, Jackson IL, Vujaskovic Z, Booth C, MacVittie TJ, Ernst RK, Kane MA. Identification and quantitation of biomarkers for radiation-induced injury via mass spectrometry. Health Phys. 2014 Jan;106(1):106-19. doi: 10.1097/HP.0b013e3182a4ed3b. PMID: 24276554. PMCID: PMC3843144

Jones JW, Tudor G, Bennett A, Farese AM, Moroni M, Booth C, MacVittie TJ, Kane MA. Development and validation of a LC-MS/MS assay for quantitation of plasma citrulline for application to animal models of the acute radiation syndrome across multiple species. Anal Bioanal Chem. 2014 Jul;406(19):4663-75. doi: 10.1007/s00216-014-7870-0. Epub 2014 May 20. PMID: 24842404

Osborne J, Djapgne L, Tran B, Goo YA, Oglesby-Sherrouse AG. (2014) A method for in vivo identification of bacterial small RNA binding proteins. Microbiology Open 3(6):950-60. PMID: 25351924

Perri M, Yap JL, Yu J, Cione E, Fletcher S, Kane MA. BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells. Exp Cell Res. 2014 Oct 1;327(2):183-91. doi: 10.1016/j.yexcr.2014.07.024. Epub 2014 Aug 1. PMID: 25088254

Pierzchalski K, Taylor RN, Nezhat C, Jones JW, Napoli JL, Yang G, Kane MA, Sidell N. Retinoic Acid Biosynthesis Is Impaired in Human and Murine Endometriosis. Biol Reprod. 2014 2014 Oct;91(4):84. doi: 10.1095/biolreprod.114.119677. Epub 2014 Aug 20. (+ Kane & Sidell are equal co-corresponding authors). PMID: 25143356. PMCID: PMC4435029

Scott AJ, Jones JW, Orschell CM, MacVittie TJ, Kane MA, Ernst RK. Mass spectrometry imaging enriches biomarker discovery approaches with candidate mapping. Health Phys. 2014 Jan;106(1):120-8. doi: 10.1097/HP.0b013e3182a4ec2f. PMID: 24276555. PMCID: PMC4015108

Snyder, G.A., Deredge, D.*, Waldhuber, A., Fresquez, T., Wilkins, D.Z., Smith, P., Durr, S., Cirl, C., Jian, J., Jennings, W., Luchetti, T., Snyder, N., Sundberg, E.J., Wintrode, P.L., Miethke, T. and Xiao, T.S. (2014) Crystal structures of the TIR domains from the Brucella protein TcpB and the host adaptor protein TIRAP reveal mechanisms of molecular mimicry. J. Biol. Chem. 289 669-679. DOI: 10.1074/jbc.M113.523407. PMID: 24275656

Tang N, Bamford P, Jones J, He M, Kane MA, Mooney SM, Bearer CF. Choline partially prevents the impact of ethanol on the lipid raft dependent functions of l1 cell adhesion molecule. Alcohol Clin Exp Res. 2014 Nov;38(11):2722-30. doi: 10.1111/acer.12554. PMID: 25421509. PMCID: PMC4244605

Wong JM, Jones JW, Jiang W, Polli JE, Kane MA. Quantification of lamotrigine in patient plasma utilizing a fast liquid chromatography-tandem mass spectrometry method with backflush technology. Ther Drug Monit. 2015 Apr;37(2):188-97. doi:10.1097/FTD.0000000000000123. PMID: 25162213

2013

Billings SE, Pierzchalski K, Butler Tjaden NE, Pang XY, Trainor PA, Kane MA, Moise AR. The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013 Dec;27(12):4877-89. doi: 10.1096/fj.13-227967. Epub 2013 Sep 4. PMID: 24005908. PMCID: PMC3834788

Healy JR, Bezawada P, Shim J, Jones JW, Kane MA, MacKerell AD Jr, Coop A, Matsumoto RR. Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities. ACS Chem Neurosci. 2013 Sep 18;4(9):1256-66. doi: 10.1021/cn4000428. Epub 2013 Jun 11. PMID: 23713721. PMCID: PMC3778426

Pauli SA, Session DR, Shang W, Easley K, Wieser F, Taylor RN, Pierzchalski K, Napoli JL, Kane MA, Sidell N. Analysis of follicular fluid retinoids in women undergoing in vitro fertilization: retinoic acid influences embryo quality and is reduced in women with endometriosis. Reprod Sci. 2013 Sep;20(9):1116-24. doi: 10.1177/1933719113477487. Epub 2013 Feb 20. PMID: 23427183. PMCID: PMC3745715

Pierzchalski K, Yu J, Norman V, Kane MA. CrbpI regulates mammary retinoic acid homeostasis and the mammary microenvironment. FASEB J. 2013 May;27(5):1904-16. doi: 10.1096/fj.12-219410. Epub 2013 Jan 29. PMID: 23362116

Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu J, Cione E, Kane MA, Fletcher S, Prochownik EV. Disruption of Myc-Max heterodimerization with improved cell-penetrating analogs of the small molecule 10074-G5. Oncotarget. 2013 Jun;4(6):936-47. Online ISSN 1949-2553. PMID: 23801058. PMCID: PMC3757250

2012

Cheng, I., Nikita, N., Fishovitz, J., Frase, H., Wintrode, P.L. and Lee, I. (2012) Identification of a region in the N-terminus of escherichia coli lon that affects ATPase, substrate translocation and proteolytic activity. J. Mol. Biol. 418 208-225. DOI: 10.1016/j.jmb.2012.02.039. PMID: 22387465

Kane MA. Analysis, occurrence, and function of 9-cis-retinoic acid. Biochim Biophys Acta. 2012 Jan;1821(1):10-20. doi: 10.1016/j.bbalip.2011.09.012. Epub 2011 Oct 1. Review. PMID: 21983272

Shao C, Dowling TC, Haidar S, Yu LX, Polli JE, Kane MA. Quantification of acyclovir in human plasma by ultra-performance liquid chromatography – heated electrospray ionization – tandem mass spectrometry for bioequivalence evaluation. J Anal Bioanal Techniques 2012, 3:4. doi: 10.4172/2155-9872.1000139.

2011

Raufman JP, Xu S, Cheng K, Khurana S, Johnson D, Shao C, Kane MA, Shi D, Gullapalli R, Polli J. In vivo magnetic resonance imaging to detect biliary excretion of 19F-labeled drug in mice. Drug Metab Dispos. 2011 May;39(5):736-9. doi: 10.1124/dmd.110.037358. Epub 2011 Jan 26. PMID: 21270105. PMCID: PMC3082377

PRESENTATIONS

The presenting author is underlined in each entry listed below.

2016

Waters Seminar - Using HDX MS to Characterize Biomolecules (Baltimore, MD) June 2016.

D. Deredge. Insights from HDX_MS into the Drug DIscovery and Development Process. Waters Seminar - Using HDX MS to Characterize Biomolecules (Baltimore, MD) June 2016. (oral presentation) 

American Society of Mass Spectrometry Annual Meeting (San Antonio, TX) June 2016.

W. Li, J. Yu, C. L. Carter, J. W. Jones, M. A. Kane. Targeted Quantitation of CrbpI in Cancer Cells through a Bottom-Up Approach. American Society of Mass Spectrometry Annual Meeting (San Antonio, TX) June 2016. (poster presentation) 

C. L. Carter, J. W. Jones, K. Hankey, A. M. Farese, T. J. MacVittie, M. A. Kane. Characterizing the Natural History of Acute Radiation Syndrome of the Castrointestinal Tract: Combining High Mas and Spatial Resolution using MALDI-FTICR-MSI. American Society of Mass Spectrometry Annual Meeting (San Antonio, TX) June 2016. (oral presentation) 

J. W. Jones, C. L. Carter, M. A. Kane. Electron-Induced Dissociation (EID) of Lipids: Diagnostic Product Ions for Confident Identification of Isomers. American Society of Mass Spectrometry Annual Meeting (San Antonio, TX) June 2016. (oral presentation) 

M. A. Kane, L. Brewer, B. Giardina, J. W. Jones, A. Nguyen, A. Oglesby-Sherrouse, A. Wilks. Discovery and Quantitative Metabolomics to Characterize Metabolites of Bacterial Origin as Biomarkers for Cystic Fibrosis. American Society of Mass Spectrometry Annual Meeting (San Antonio, TX) June 2016. (oral presentation)

Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD). January 2016 

P. Wintrode; Hydrogen/Deuterium Exchange (HDX) in conjunction with mass spectrometry to learn how dynamics mediate the function and inhibition of proteins. Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD). January 2016 Meeting (oral presentation).

2015

Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD). November and June 2015

S. Michel; ICP-MS to the Rescue: Counting Metal Ions in Metalloproteins, Tissues and Plasma. Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD). November 2015 Meeting (oral presentation).

W. Li; B. Tran; S. H. Yoon; K. Pierzchalski; J. Yu; D. R. Goodlett; M. A. Kane; Use of Native Mass Spectrometry for Quantification of Protein Complex. Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD). June 2015 Meeting (oral presentation).

Asilomar Conference on Native Mass Spectrometry, October 2015

W. Li, M.A. Kane. Quantitative Analysis of Noncovalent Protein Complex Through Native Mass Spectrometry; Asilomar Conference on Mass Spectrometry. (poster presentation and selected for an oral “Poster Highlight” talk)  *Wenjing won a “Best Student Presentation” Award.

American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015.

C. L. Carter, J. W. Jones, I. L. Jackson, Z. Vujaskovic, S. Kearney, K. Barrow, A. Gibbs, K. Kieta, C. Taylor-Howell, A. M. Farese, T. J. MacVittie, M. A. Kane. Application of MALDI-MSI to identify biomarkers of radiation-induced lung injury and medical countermeasure development. American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015. (oral and poster presentation).,

J. W. Jones, C. L. Carter, G. Tudor, A. Bennett, A. M. Farese, C. Booth, T. J. MacVittie, M. A. Kane. Lipidomic Profiling of Plasma from Radiation Animal Models. American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015. National. (poster presentation).

J. W. Jones, C. L. Carter, G. Tudor, A. Bennett, A. M. Farese, I. L. Jackson, Z. Vujaskovic, C. Booth, T. J. MacVittie, M. A. Kane. Analysis of radiation-induced injury by targeted high-throughput metabolomics. American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015. (poster presentation).

L. (J.) Wang; J. W. Jones; M.A. Kane; P. R.S. Baker; Retinoic Acid Analysis with Differential Mobility Mass Spectrometry for Improved Selectivity and Sensitivity. American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015. (poster presentation).

W. Li; B. Tran; S. H. Yoon; K. Pierzchalski; J. Yu; D. R Goodlett; M. A Kane; Use of Native Mass Spectrometry for Quantification of Protein Complex. American Society of Mass Spectrometry Annual Meeting (St. Louis, MO) June 2015. (poster presentation).

NIAID Radiation and Nuclear Group Meeting (Bethesda, MD). May 2015.

M.A. Kane. Mass Spectrometry Imaging: Molecular Imaging and Biomarkers. NIAID RNG Meeting (Bethesda, MD). May 2015. (oral presentation).

ConRad Global Conference on Radiation (Munich, Germany) May 2015

J. W. Jones, C. L. Carter, F. Li, G. Tudor, A. Bennett, S. Kearney, C. Taylor-Howell, C. P. Smith, A. M. Farese, Y. Tong, B. Katz, C. Booth, T. J. MacVittie, M. A. Kane. Targeted and Discovery-based Mass Spectrometry Metabolomics for Biomarker Identification and Validation in Mouse and Non-Human Primate Radiation Models. ConRad Global Conference on Radiation (Munich, Germany) May 2015. (oral presentation).

C. L. Carter, J. W. Jones, I. L. Jackson, Z. Vujaskovic, S. Kearney, K. Barrow, A. Gibbs, A. M. Farese, T. J. MacVittie,  M. A. Kane . Imaging Molecular Changes in the Lung Following Whole Thorax Irradiation +/- AEOL10150 treatment using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. ConRad Global Conference on Radiation (Munich, Germany) May 2015. (poster presentation).

J. W. Jones, C. L. Carter, F. Li, K. Pierzchalski, P.-T. Xu, I. L. Jackson, Z. Vujaskovic, M. A. Kane. Lipidomic Studies of Lung Tissue from the Whole Thorax Lung Irradiation Mouse Model: Detection, Visualization, and Quantification of Lung Lipid Biomarkers. ConRad Global Conference on Radiation (Munich, Germany) May 2015. (poster presentation).

8th Annual Frontiers in Chemistry and Biology Interface (Baltimore, MD) May 2015

D. Deredge, J. Li, K. Johnson, P. Wintrode. Conformational basis of HCV RNA-dependent RNA polymerase inhibition by allosteric Thumb II site inhibitors. 2015, 8th Annual Frontiers in Chemistry and Biology Interface. Awarded poster prize. (poster & presentation)

Experimental Biology (Boston, MA) March 2015

M.A. Kane. Retinoic acid biosynthesis defects in cancer. Carotenoid and Retinoid Interest Group (CARIG) Symposium prior to Experimental Biology Meeting (Boston, MA) March 27, 2015. (oral presentation).

Biophysical Society 59th Annual Meeting (Baltimore, MD) February 2015 

D.Deredge, K. Johnson, P. Wintrode. Thumb II Site Inhibitor Allosterically Suppresses the Dynamics of HCV RNA-Dependent RNA Polymerase. Biophys. 108 , Issue 2,  2015, 59th Annual Biophysical Society meeting (poster presentation)

2014

CMCR Workshop II: Mitigation and Treatment of Radiation Injury (Baltimore, MD) October 2014

C.L. Carter, J.W. Jones, M.A. Kane. MALDI-MSI to identify changes in the lipid profiles as they relate to radiation damage and mitigation.  CMCR Workshop II: Mitigation and Treatment of Radiation Injury (Baltimore, MD).  October 8, 2014. (oral presentation).

Radiation Research Society. (Las Vegas, NV). September 2014

J. W. Jones, K. Pierzchalski, J. Yu, C. L. Carter, Fei Li, G. Tudor, A. Bennett, A. M. Farese, I. L. Jackson, Z. Vujaskovic,C. Booth, T. J. MacVittie, M. A. Kane. Metabolomic analysis reveals radiation disrupts essential nutrient signaling nodes. Radiation Research Society. (Las Vegas, NV). September 2014. (poster presentation).

J. W. Jones, F. Li, C. L. Carter, G. Tudor, A. Bennett, A. M. Farese, Y. Tong, B. Katz, C. Booth, T. J. MacVittie, M. A. Kane. Targeted and Discovery-based Mass Spectrometry Metabolomics for Biomarker Identification and Validation in Mouse and Non-Human Primate Radiation Models. Radiation Research Society (Las Vegas, NV). September 2014. (poster presentation).

C. L. Carter, J. W. Jones, I. L. Jackson, Z. Vujaskovic, S. Tabisz, S. Kearney, A. Gibbs, J. Harper, K. Barrow, A. M. Farese, T. J. MacVittie, M. A. Kane. Using MALDI-MSI to enable biomarker identification and medical countermeasure development for radiation-induced lung injury. Radiation Research Society, (Las Vegas, NV).  September 2014. (poster presentation).

FASEB Summer Research Conference on Retinoids / Second International Retinoid Meeting, (Itasca, IL). June 2014

J.W. Jones, K. Pierzchalski, J. Yu,M. A. Kane. “Quantitative profiling of retinoid homeostasis.” Invited speaker at FASEB Summer Research Conference on Retinoids / Second International Retinoid Meeting, (Itasca, IL). June 2014. (oral presentation).

J. Yu, K. Pierzchalski, J. W. Jones, M. A. Kane. Targeted metabolomic analysis to interrogate the role of cellular retinol-binding protein, type 1 in retinoic acid biosynthesis. FASEB Summer Research Conference on Retinoids / Second International Retinoid Meeting, (Itasca, IL). June 2014. (poster presentation).

K. Pierzchalski, C. Nezhat , J. L. Napoli , G. Yang , N. Sidell , M. A. Kane. Retinoic Acid Biosynthesis is Impaired in Endometriosis. FASEB Summer Research Conference on Retinoids / Second International Retinoid Meeting, (Itasca, IL). June 2014. (poster presentation).

American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014

C. L. Carter, J. W. Jones , I. L. Jackson , Z. Vujaskovic, S. Tabisz, A. Gibbs, J. Harper, K. Barrow, A. M. Farese, T. J. MacVittie, M. A. Kane MALDI-MSI Lipidomic Investigation into the Delayed Effect of Acute Radiation Exposure: The Lung Syndrome and the Efficacy of a Medical Countermeasure.  American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).

D. Deredge, C. Liu, V. LiCata, P. Wintrode. Dynamic Signatures of Thermal Adaptation in DNA Polymerases Observed by Hydrogen Exchange. 2014, ASMS Conference on Mass Spectrometry and Allied Topics. June 2014. (poster presentation).

J. W. Jones, F. Li, C. L. Carter, K. Pierzchalski, P.-T. Xu, I. L. Jackson, Z. Vujaskovic, M. A. Kane. Identification of Lipid Biomarkers from Mouse Lung Tissue via the Use of UPC2 Tandem Mass Spectrometry. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).

J. W. Jones, C. J. Thompson, C. L. Carter, G. Tudor, C. Booth, I. L. Jackson, Z. Vujaskovic, T. J. MacVittie, M. A. Kane. Electron-Induced Dissociation (EID) of physiologically relevant phospholipids and glycophospholipids. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).

F. Li, J. W. Jones, G. Tudor, C. Booth, T. J. MacVittie, M. A. Kane Disruption of amino acid metabolism in radiation-induced lung injury. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).

W. Li, J. W. Jones, J. Yu, K. Pierzchalski, P.-T. Xu, I. L. Jackson, Z. Vujaskovic, G. Tudor, C. Booth, T. J. MacVittie, M. A. Kane. Metabolite profiling of active metabolites of vitamin A in lung epithelial cells. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).

K. Pierzchalski, J. W. Jones, C. Booth, G. Tudor, A. Bennett, A. M. Farese, T. J. MacVittie, P.-T. Xu, I. L. Jackson, Z. Vujaskovic, M. A. Kane. Application of multistage tandem mass spectrometry for quantification of endogenous metabolites in lung tissue. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).

B. Tran, C. Booth, G. Tudor, W. Li, Y. A. Goo, T. J. MacVittie,D. R. Goodlett, M. A. Kane Label-free quantitative analysis of radiation-induced differential protein expression in the mouse lung proteome. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).

J. Yu, J. W. Jones, K. Pierzchalski, M. A. Kane. Targeted metabolomic analysis to interrogate the role of cellular retinol-binding protein, type 1 in retinoic acid biosynthesis. American Society of Mass Spectrometry Annual Meeting (Baltimore, MD). June 2014. (poster presentation).

Waters User Meeting (Baltimore, MD) June 2014 

J. W. Jones , K. Pierzchalski , J. Yu , C. Carter , F. Li , I. L. Jackson , Z. Vujaskovic , A. Bennett , A. M. Farese , E. Farias, T. J. MacVittie , and M. A. Kane  “Metabolomics to characterize tissue damage, dysfunction and repair” Invited seminar at Waters User Meeting at American Society of Mass Spectrometry (Baltimore, MD). June 2014. (oral presentation).

Mid-Atlantic Directors and Staff of Scientific Cores Meeting, (Baltimore, MD). June 2014

C. L. Carter, J. W. Jones, K. Pierzchalski, J. Yu, B. Tran, W. Li,  M. A. Kane  “MALDI-MSI Macromolecular Localization and Biomarker Discovery” Mid-Atlantic Directors and Staff of Scientific Cores 2014 Meeting,  (Baltimore). June 2014. (oral presentation).

Frontiers at the Chemistry-Biology Interface Symposium (Baltimore, MD). May 2014

J. W. Jones , K. Pierzchalski , J. Yu , C. Carter , F. Li , I. L. Jackson , Z. Vujaskovic , A. Bennett , A. M. Farese, E. Farias, T. J. MacVittie, and M. A. Kane  Metabolomics to characterize tissue damage, dysfunction and repair. Frontiers at the Chemistry-Biology Interface Symposium (Baltimore, MD). May 2014. (oral presentation).

M-CERSI Conference:  MALDI-Mass Spectrometry Imaging of Drug Metabolism (Baltimore, MD). April 2014

C. L. Carter, J. W. Jones, I. L. Jackson, Z. Vujaskovic, S. Tabisz, S. Kearney, K. Barrow, A. Gibbs, A. M. Farese, T. J. MacVittie, M. A. Kane. Mass Spectrometry Imaging in the Development of Medical Countermeasures Against Radiological Threat. M-CERSI Conference: MALDI-Mass Spectrometry Imaging of Drug Metabolism (Baltimore, MD). April 2014. (oral presentation).

Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD). April 2014

J.W. Jones, K. Pierzchalski, J. Yu, M.A. Kane. Fast HPLC and MRM3 for Retinoic Acid Quantitation in Complex Matrices: Use of targeted metabolomics to probe retinoid metabolism

Washington-Baltimore Mass Spectrometry Discussion Group (Columbia, MD). April 2014. (oral presentation).

Waters Metabolomics Seminar (Columbia, MD). March 2014.

J. W. Jones, K. Pierzchalski, J. Yu, C.L. Carter, F. Li, I. L. Jackson, Z. Vujaskovic, A. Bennett, A. M. Farese, E. Farias, T. J. MacVittie, M. A. Kane  Metabolomics to characterize tissue damage, dysfunction and repair. Waters Metabolomics Seminar (Columbia, MD). March 2014. (oral presentation). 

2013

Radiation Research Society. (New Orleans, LA). September 2013

C. L. Carter, J. W. Jones, A. J. Scott, Y. A. Goo, A. Plett, C. M. Orschell, D. R. Goodlett, R. K. Ernst, M. A. Kane. Biomarker Discovery and Validation: Coupling MALDI Imaging to Proteomic Expression and Metabolite Quantitation to Characterize Radiation-Induced Tissue Damage. Radiation Research Society Meeting (New Orleans, LA). September 2013. (poster presentation)

J. W. Jones, A. Bennett, A. M. Farese, T. J. MacVittie, M. A. Kane. Biomarker Discovery for Radiation Induced Tissue Damage Via Un-Targeted Mass Spectrometry Based Metabolomics. Radiation Research Society Meeting (New Orleans, LA). September 2013. (poster presentation)

J. W. Jones, G. Tudor, A. Bennett, A. M. Farese C. Booth, T. J. MacVittie, M. A. Kane. Evaluation of Citrulline as a Biomarker for Radiation-Induced Gastrointestinal Tissue Damage. Radiation Research Society Meeting (New Orleans, LA). September 2013. (poster presentation)

First International Retinoids Meeting (Calabria, Italy). September 2013

K. Pierzchalski , J. Yu , J. W. Jones , C. Carter , Y. A. Goo , B. Tran , A. J. Scott , I. L. Jackson , Z. Vujaskovic , C. Booth , G. Tudor , A. Plett , C. M. Orschell , R. K. Ernst , D. R. Goodlett , A. Bennett , A. M. Farese , T. J. MacVittie , and M. A. Kane. Profiling of endogenous retinoids: Radiation alters retinoid homeostasis. First International Retinoids Meeting (Calabria, Italy). September 2013. (oral presentation).

K. Pierzchalski, M.A. Kane. Impact of CrbpI and retinoic acid on endometriosis. First International Conference on Retinoids (Calabria, Italy) September 2013. (oral and poster presentation).

M. Perri, J. Yap, S. Fletcher, E. Cione,  M.A. Kane. Combined doses of the dual Bcl-xL/Mcl-1 inhibitor JY-1-106 and a selective RARγ antagonist work cooperatively but in different manner in human leukemia and breast cancer cells. First International Conference on Retinoids (Calabria, Italy). September 2013. (oral and poster presentation).

K. Pierzchalski, J. Yu, J. W. Jones, C. Carter*, Y. A. Goo , B. Tran, A. J. Scott , I. L. Jackson, Z. Vujaskovic, C. Booth, G. Tudo , A. Plett , C. M. Orschell, R. K. Ernst, D. R. Goodlett, A. Bennett, A. M. Farese, T. J. MacVittie, M. A. Kane. Radiation alters retinoid homeostasis. First International Retinoids Meeting (Calabria, Italy). September 2013. (poster presentation).

NIAID Radiation and Nuclear Group Meeting (Bethesda, MD). June 2013.

M. A. Kane, J. W. Jones, A. Scott, G. Tudor, A. Bennett, A. M. Farese, C. Booth, C. M. Orschell, I. L. Jackson, R. K. Ernst, Z. Vujaskovic, T. J. MacVittie.  Citrulline as a biomarker of radiation-induced damage and the use of mass spectrometry based techniques to characterize radiation-induced tissue damage. NIAID RNG Meeting (Bethesda, MD). June 2013. (oral presentation).

American Society for Mass Spectrometry Conference (Minneapolis, MN). June 2013.

J. W. Jones, A. J. Scott, K. Pierzchalski, Y. A. Goo, C. L. Carter, A. Plett, C. M. Orschell, D. R. Goodlett, R. K. Ernst, M. A. Kane. Biomarker Discovery and Validation: Coupling Mass Spectrometry Imaging to Proteomic Expression and Metabolite Quantitation to Characterize Radiation-Induced Tissue Damage. 61st American Society for Mass Spectrometry Conference (Minneapolis, Minnesota). June 2013. (poster presentation)

J. W. Jones, A. Bennett, G. Tudor, K. Pierzchalski, B. Q. Tran, A. M. Farese, C. Booth, T. J. MacVittie, M. A. Kane. Biomarker Discovery for Radiation Induced Tissue Damage Via Targeted and Un-Targeted Mass Spectrometry Based Metabolomics. 61st American Society for Mass Spectrometry Conference (Minneapolis, Minnesota). June 2013. (poster presentation)

ConRad Global Conference on Radiation (Munich, Germany). May 2013.

J. W. Jones*, G. Tudor, C. Booth, T. J. MacVittie,M. A. Kane. Evaluation of Citrulline as a Biomarker for Radiation-Induced Gut Damage. Global Conference of Radiation Topics (Munich, Germany). May 2013. (oral and poster presentation). +chosen for oral presentation.

US Human Proteome Organization Meeting, (Baltimore, MD) March 2013.

J.Jones, A. Scott, Y.A. Goo, A. Plett, C. Orschell, R.K. Ernst, D.R. Goodlett, M.A. Kane. Proteomic biomarker discovery and validation: coupling MALDI Imaging and LC ESI tandem mass spectrometry to characterize radiation-induced tissue damage. US Human Proteome Organization Meeting, (Baltimore, MD) March 2013. (poster presentation) 

2012

American Epilepsy Society Meeting, (San Diego, CA). December 2012.

J. Wong, W. Jiang, T. Ting, J.E. Polli, M.A. Kane. A liquid chromatography-tandem mass spectrometry method for the quantification of lamotrigine in patient plasma.  American Epilepsy Society Meeting, (San Diego, CA). December 2012.. (poster presentation)

Computer Aided Drug Design Center Symposium, School of Pharmacy, University of Maryland, Baltimore (Baltimore, MD). July 2012.

M.A. Kane. Mass spectrometry in drug design: quantitative profiling of endogenous metabolites by LC-MS/MS. Computer Aided Drug Design Center Symposium, School of Pharmacy, University of Maryland, Baltimore (Baltimore, MD). July 2012. (oral presentation). 

FASEB Retinoid Summer Research Conference (Snowmass, CO). June 2012.

M.A. Kane. Retinoic acid biosynthesis defects in cancer: profiling endogenous retinoic acid by LC-MS/MS. FASEB Retinoid Summer Research Conference (Snowmass, CO). June 2012. (oral presentation).

K. Pierzchalski, J. Yu, M.A. Kane. Impact of CrbpI on mammary retinoic acid homeostasis. oral and poster presentation at FASEB Summer Research Conference on Retinoids (Snowmass, CO). June 2012. (oral  and poster presentation). +chosen for oral presentation. ++KP awarded a Graduate Student Travel Award for this work.

J. Yu, K. Pierzchalski, M.A. Kane. RA homeostasis in mammary epithelial cells. FASEB Summer Research Conference on Retinoids, (Snowmass, CO). June 2012. International.

2011

EMBO Retinoids Conference, (Strasbourg, France) September 2011.

M.A. Kane. Retinoic Acid Biosynthesis Defects in Cancer. EMBO Retinoids Conference, (Strasbourg, France) September 2011. (oral and poster presentation).

Experimental Biology (Washington, DC) April 2011

M. A. Kane, C. Shao, A. Pingitore, K. Pierchalski Quantitative assessment of endogenous retinoids in breast cancer models. Experimental Biology National Meeting – American Society for Investigative Pathology session on Neoplasia (Washington, DC). April 2011. (poster presentation)

A.  Pingitore, M. Perri, E. Cione, M. A. Kane. Altered retinoid metabolism in breast cancer.  Experimental Biology National Meeting – American Society for Investigative Pathology session on Neoplasia (Washington, DC). April 2011. (poster presentation)