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Chris Cunningham |
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Andy's homepage : E-mail Chris
: Chris' CV |
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Chris is a
graduate student in the department. He is working on the development of
opioid analgesics with reduced levels of
constipation. Funding: Honors
and Awards: Invited
Lectures: Publications: C.W.
Cunningham; L.N. Thatcher; A. Coop. Methylation
of non-acidic alcohols of alkaloids with TMS-diazomethane: conversion of
codeine to codeine-6-methyl ether. Heterocycles,
2006, 68(4): 837-40. S.L. Mercer;
H.E. Hassan; C.W. Cunningham; N.D. Eddington; A. Coop. Opioids
and efflux transporters. Part 1: P-Glycoprotein substrate activity
of N-substituted analogs of meperidine.
Bioorg. Med. Chem. Lett.,
2007, 17(5): 1160-2. C.W.
Cunningham; S.L. Mercer; H.E. Hassan; J.R. Traynor; N.D. Eddington; A.
Coop. Opioids and efflux transporters.
Part 2: P-Glycoprotein substrate activity of 3- and 6-substituted morphine
analogs. J. Med. Chem., 2008,
51: 2316-20. S.L. Mercer;
C.W. Cunningham; N.D. Eddington; A. Coop. Opioids and
efflux transporters. Part 3:
P-Glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs.
Bioorg. Med. Chem. Lett.,
2008 (provisionally accepted). H.E. Hassan; S.L. Mercer; C.W. Cunningham; A. Coop; N.D. Eddington. Evaluation of the P-glycoprotein
affinity status of a series of novel and currently available morphine
analogs: Comparative study with meperidine analogs
to identify compounds with minimal P-gp
interactions. Int.
J. Pharmaceutics, 2008 (provisionally accepted). Reviews: Posters: C.W.
Cunningham; L.N. Thatcher; A. Coop. TMS-diazomethane as a methylating agent in the synthesis
of codeine-6-methyl ether. Abstracts of the College on Problems of Drug Dependence, Orlando,
FL. June, 2005. H. Hassan; C.W. Cunningham; A. Coop; N.D. Eddington. Effect of the ABC transport proteins on
the uptake, transport and tolerance development to selected opioids. International Society for the Study of Xenobiotics, Maui, HI. October, 2005. H. Hassan; C.W. Cunningham; A. Coop; N.D. Eddington. Effect of potent and specific P-gp inhibitors on the transport of selected opioids across Caco-2 cells and MDCKII-MRP1. American Association of Pharmaceutical Sciences,
Nashville, TN. November, 2005. C.W.
Cunningham; S.L. Mercer; H. Hassan; N.D. Eddington; A. Coop. Effect of 3- and 6-substitution
on P-gp substrate activity of morphine
analogs. University of Maryland School of Pharmacy Annual Research
Day, Baltimore, MD. May, 2006. S.L. Mercer;
C.W. Cunningham; H. Hassan; N.D. Eddington; A. Coop. The relative activity of meperidine analogs as P-glycoprotein substrates. University
of Maryland School of Pharmacy Annual Research Day, Baltimore, MD.
May, 2006. S.L. Mercer; C.W.
Cunningham; H. Hassan; N.D. Eddington;
A. Coop. The relative activity of opioids as
P-glycoprotein substrates. Abstracts of the College on Problems of Drug Dependence,
Scottsdale, AZ. June, 2006. C.W.
Cunningham; H. Hassan; S.L. Mercer; N.D. Eddington; A. Coop. Diminished P-gp substrate activity of 3- and 6-substituted morphine
analogs. International Narcotics
Research Conference, St. Paul, MN. July, 2006. C.W. Cunningham; D. Bernard; H. Wu; C. Acharya;
H. Wang; J-B. Wang; A. Coop, A.D. MacKerell
Jr. Validation of a quantitative conformationally
sampled pharmacophore for δ opioid ligands. University
of Maryland School of Pharmacy Annual Research Day, Baltimore, MD.
May, 2007. C.W. Cunningham; D. Bernard; H. Wu; M.D. Metcalf; C. Acharya; H. Wang; J-B. Wang; A.D. MacKerell
Jr; A. Coop. δ Opioid ligand efficacy
prediction using a quantitative conformationally
sampled pharmacophore. International Narcotics Research Conference,
Berlin, Germany. July, 2007. S.L. Mercer; C.W. Cunningham; H.E. Hassan;
N.D. Eddington; A. Coop. The relative
activity of meperidine analogs as P-glycoprotein
substrates. International
Narcotics Research Conference, Berlin, Germany. July, 2007. |
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