James E. Polli
University of Maryland School of Pharmacy
Department of Pharmaceutical Sciences
HSF II, Room 623
20 Penn Street
Baltimore, MD 21201
(410) 706-8292
FAX (410) 706-5017
jpolli@rx.umaryland.edu

directions and visitor parking at Baltimore Grand Garage on Paca Street at Baltimore Street
The Baltimore Grand Garage is located at 5 North Paca Street, Baltimore, MD 21201

EDUCATION
B.S. ( Pharmacy ) - Philadelphia College of Pharmacy and Science, 1989
Ph.D. ( Pharmaceutics ) - University of Michigan, 1993

RESEARCH INTERESTS
The overall interest of the laboratory is oral drug absorption. The laboratory's two main research themes deal with the inclusion of bioavailability considerations in drug design and the pharmacokinetic evaluation of oral solid dosage forms. Ongoing graduate student projects are in the areas of prodrug design to target intestinal absorptive transporters, chemical structure-permeability relationships, drug dissolution and in vitro-in vivo correlation, and novel methods to assess bioequivalence. I provide volunteer service to various agencies around the world to promote international drug quality standards, with special emphasis on the assurance of oral drug bioavailability.

SELECTED RECENT PUBLICATIONS

Tolle-Sander, S., Lentz, K.A., Maeda, D.Y., Coop, A., and Polli, J.E. (2004): Increased acyclovir oral bioavailability via a bile acid conjugate. Mol. Pharm. 1:40-48.

Polli, J.E., Yu, L.X., Cook, J.A., Amidon, G.L., Borchardt, R.T., Burnside, B.A., Burton, PS., Chen, M.-L., Conner, D.P., Faustino, .J., Hawi, A.A., Hussain, A.S. Joshi, HN., Kwei, G. Lee, V.H.L., Lesko, L.J., Lipper, R.A., Loper, A.E., Nerurkar, S.G., Polli, J.W. Sanvordeker, D.R., Taneja, R., Uppoor, R.S., Vattikonda, C.S., Wilding, I., and Zhang, G. (2004): Summary Workshop Report: Biopharmaceutics Classification System – Implementation Challenges and Extension Opportunities. J. Pharm. Sci. 93:1375-1381.

Balakrishnan, A., Wring, S.A., Coop, A., and Polli, J.E. (2006): Influence of Charge and Steric Bulk in C-24 Region on the Interaction of Bile Acids with Human Apical Sodium Dependent Bile Acid Transporter. Mol. Pharm. 3:282-292.

Seo, P.R., Teksin, Z.S., Kao, J.P.Y., and Polli, J.E.: Lipid Composition Effect on Permeability Across PAMPA. In press in Eur. J. Pharm. Sci.

SELECTED PREVIOUS PUBLICATIONS

Polli, J.E. and Amidon, G.L. (1995): Mathematical model and dimensional analysis of glycocholate binding to cholestyramine resin: implications for in vivo resin performance. J. Pharm. Sci. 84:1446-1454.

Polli, J.E., Crison, J.R., and Amidon, G.L. (1996): A novel approach to the analysis of in vitro-in vivo relationships. J. Pharm. Sci. 85:753-760.

Polli, J.E., Rekhi, G.S., Augsburger, L.L., and Shah, V.P. (1997) Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartrate tablets. J. Pharm. Sci. 86:690-700.

Polli, J.E. and Ginski, M.J. Human drug absorption kinetics and comparison to Caco-2 monolayer permeabilities. Pharm. Res. 15:47-52 (1998).

Ginski, M.J., Taneja, R., and Polli, J.E. (1999): Prediction of dissolution-absorption relationships from a continuous dissolution/Caco-2 system. PharmSci 1(2): [serial on the internet]. June 3, 1999; Approx. size: 76k + 156k in images. Available from: http://www.pharmsci.org/journal.

Lentz, K.A., Hayashi, J., Lucisano, L.J. and Polli, J.E. Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to biopharmaceutics classification system (2000). Int. J. Pharm. 200(1): 41-51.

Polli, J.E. IVIVR vs. IVIVC. (2000). Dissolution Technologies 7(3): 6-16.

Lentz, K.A., Polli, J.W., Wring, S.A., Humphreys, J.E., and and Polli, J.E. (2000): Influence of passive permeability on apparent P-glycoprotein kinetics. Pharm. Res. 17: 1456-1460.

Polli, J.E. and McLean A.M. (2001) Novel direct curve comparison metrics for bioequivalence. Pharm. Res. 18:734-741.

Rege, B.D., Yu, L.X., Hussain, A.S., and Polli, J.E. (2001). Effect of common excipients on Caco-2 transport of low permeability drugs. J. Pharm. Sci. 90:1776-1786.

Seo, P.R., Shah, V.P., and Polli, J.E. (2002). Novel metrics to compare dissolution profiles. Pharm. Dev. Technol. 7:223-231.

Rege, B.D., Kao, J.P.Y., and Polli, J.E. (2002): Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur. J. Pharm Sci. 16:237-246.

Tolle-Sander, S., Rautio, J., Wring, S., Polli, J.W., and Polli, J.E. (2003): Midazolam exhibits characteristics of a highly permeable P-glycoprotein substrate. Pharm. Res. 20:757-764.

Tolle-Sander, S., Grill, A., Joshi, H., Kapil, R., Persiani, S., and Polli, J.E. (2003): Characterization of dexloxiglumide in vitro biopharmaceutic properties and active transport. J. Pharm. Sci. 92:1968-1980.

Polli, J.E., Kim, S., and Martin, B. (2003): Dose uniformity from split tablets and Veterans Affairs policy. J. Managed Care Pharm. 9:305-311.

Balakrishnan, A., Rege, B.D., Amidon, G.L., and Polli, J.E. (2004): Surfactant-mediated dissolution: contributions of solubility enhancement and relatively low micelle diffusivity. J. Pharm. Sci. 93:2064-2075.

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