A tentative schedule of events for Top-Down Analysis of Antibodies is provided below for your convenience.
This is a one-day conference scheduled for Friday, June 20, 2014 at the University of Maryland School of Pharmacy, located at 20 N. Pine Street in Baltimore, MD. The conference is open to the public. Download a printer-friendly version of the agenda here.
Morning Session:
Moderators: Young Ah Goo, PhD, and Maureen Kane, PhD
| Time | Activity |
|---|---|
| 8:50-9:00 a.m. | Welcome and Introduction David Goodlett, PhD Isaac E. Emerson Chair of Pharmaceutical Sciences Director, Mass Spectrometry Center University of Maryland School of Pharmacy |
| 9:00-9:25 a.m. | The NIST mAb: A Reference Material for Biopharmaceutical Method Evaluation John Schiel, PhD Research Chemist Biomolecular Measurement Division National Institute of Standards and Technology |
| 9:25-9:50 a.m. | Mass Accurate Analysis of Protein Therapeutics: Assessment of Top Down Approaches Michael Boyne, PhD Research Chemist Division of Pharmaceutical Analysis Food and Drug Administration |
| 9:50-10:15 a.m. | Analysis of Antibody-Auristatin Conjugates for Cancer Therapy Shawna Hengel, PhD Scientist Seattle Genetics |
| 10:15-10:40 a.m. | Coffee Break |
| 10:40-11:05 a.m. | Mass Spectrometry Strategies for Rapid and Artifact-Free Antibody Structure Analysis Yury Tsybin, PhD Assistant Professor of Physical and Bioanalytical Chemistry Head, Biomolecular Mass Spectrometry Laboratory Director, Mass Spectrometry Service Facility École Polytechnique Fédérale de Lausanne (EPFL) |
| 11:05-11:30 a.m. | Protein Footprinting for Problem Solving in Biophysics Michael Gross, PhD Professor, Department of Chemistry Professor of Immunology and Internal Medicine Washington University School of Medicine |
| 11:30-11:55 a.m. | Structural Characterization of Biosimilars by HDX and Top Down Analysis Using EDC/EDT-FTMS Christoph Borchers, PhD Chief Scientific Officer, MRM Proteomics, Inc. Professor and Director, Genome British Columbia Proteomics Centre University of Victoria, Canada |
| 11:55-12:40 p.m. | Lunch |
| 12:40-1:00 p.m. | Tour of Mass Spectrometry Center |
Afternoon Session:
Moderator: Michael Przybylski, PhD, and Michael Glocker, PhD
| Time | Activity |
|---|---|
| 1:00-1:25 p.m. | UV Photodissociation for Characterization of Intact Proteins Jenny Brodbelt, PhD William H. Wade Endowed Professor in Chemistry Chair, Department of Chemistry University of Texas at Austin |
| 1:25-1:50 p.m. | Surface-induced Dissociation/Ion Mobility Characterization of Non-covalent Complexes Vicki Wysocki, PhD Professor and Ohio Eminent Scholar Department of Chemistry and Biochemistry Director, Campus Chemical Instrument Center Ohio State University |
| 1:50-2:15 p.m. | Online Biosensor-/Affinity- Mass Spectrometry for Structure Determination and Quantification of Protein Interactions from Biological Material Michael Przybylski, PhD Professor & Director Steinbeis Center for Biopolymer Analysis & Biomedical Mass Spectrometry University of Konstanz & Rüsselsheim, Germany |
| 2:15-2:40 p.m. | Defining the Stoichiometry and Cargo Load of Viral and Bacterial Nanoparticles by Orbitrap Mass Spectrometry Joost Snijder, MSc Graduate Student (Albert Heck's Lab) Utrecht University, Netherlands |
| 2:40-3:05 p.m. | A Novel Strategy for Rapid Preparation and Isolation of Intact Immune Complexes Michael Glocker, PhD Director, Proteome Center Rostock University of Rostock, Germany |
| 3:05-3:30 p.m. | Coffee Break |
| 3:30-3:55 p.m. | HDX-MS: Effects of Small Molecule Ligands on the Conformational Dynamics of the Farnesoid X Receptor Ligand Binding Domain Claudia Maier, PhD Associate Professor of Chemistry Oregon State University |
| 3:55-4:20 p.m. | Title TBA David Clemmer, PhD Associate Dean for the Sciences, College of Arts and Sciences Professor and Robert & Marjorie Mann Chair Department of Chemistry Indiana University, Bloomington |
| 4:20-4:45 p.m. | A Mass Spectrometry-based Functional Assay for Monitoring Intrinsic Proteolytic Activity in Human Serum Samples Jing-Zhi Yang, MSc Proteome Center Rostock University of Rostock, Germany |
| 4:45-5:10 p.m. | Title TBA Brian Chait, DPhil Camille and Henry Dreyfus Professor Laboratory of Mass Spectrometry and Gaseous Ion Chemistry The Rockefeller University |
| 5:10 p.m. | Concluding Remarks Michael Glocker, PhD Director, Proteome Center Rostock University of Rostock |