Recent publications from faculty in the Clinical Pharmacology Unit (CPU) at the University of Maryland School of Pharmacy are listed below.

Jones JM, Dowling TC, Park JJ, Phares DA, Park JY, Obisesan T, Brown MD. Differential Aerobic Exercise-Induced Changes in Plasma Aldosterone between African American and White Prehypertensives & Hypertensives May Be Dependent on Baseline Plasma Aldosterone Levels. Exp Physiol. 2007 May 4; [Epub ahead of print]

Edelman MJ, Bauer KS Jr, Wu S, Smith R, Bisacia S, Dancey J. Phase I and pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors. Clin Cancer Res. 2007 May 1;13(9):2667-74.

Jones-Burton C, Vessal G, Brown J, Dowling TC, Fink JC. Urinary cotinine as an objective measure of cigarette smoking in chronic kidney disease. Nephrol Dial Transplant. 2007 Mar 17; [Epub ahead of print]

Dezube BJ, Krown SE, Lee JY, Bauer KS, Aboulafia DM. Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study. J Clin Oncol. 2006 Mar 20;24(9):1389-94.

Jones J, Park JJ, Dowling T, Phares D, Park JY, Brown M. Role of potassium excretion and percent body fat on ethnic differences in plasma aldosterone levels. Ethn Dis. 2006 Summer;16(3 Suppl 4):S4-10-4.

Jones JM, Park JJ, Johnson J, Vizcaino D, Hand B, Ferrell R, Weir M, Dowling T, Obisesan T, Brown M. Renin-angiotensin system genes and exercise training-induced changes in sodium excretion in African American hypertensives. Ethn Dis. 2006 Summer;16(3):666-74.

Upreti VV, Khurana M, Cox DS, Eddington ND. Determination of endogenous glycosaminoglycans derived disaccharides in human plasma by HPLC: validation and application in a clinical study. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 2;831(1-2):156-62. 27.

Syed SA, Kamimori GH, Kelly W, Eddington ND. Multiple dose pharmacokinetics of caffeine administered in chewing gum to normal healthy volunteers. Biopharm Drug Dispos. 2005 Dec;26(9):403-9.

Karp JE, Passaniti A, Gojo I, Kaufmann S, Bible K, Garimella TS, Greer J, Briel J, Smith BD, Gore SD, Tidwell ML, Ross DD, Wright JJ, Colevas AD, Bauer KS. Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D- rabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias. Clin Cancer Res. 2005 Dec 1;11(23):8403-12.

Dowling TC, Chavaillaz PA, Young DG, Melton-Celsa A, O'Brien A, Thuning-Roberson C, Edelman R, Tacket CO. Phase 1 safety and pharmacokinetic study of chimeric murine-human monoclonal antibody c alpha Stx2 administered intravenously to healthy adult volunteers. Antimicrob Agents Chemother. 2005 May;49(5):1808-12.

Raje S, Cornish J, Newman AH, Cao J, Katz JL, Eddington ND. Pharmacodynamic assessment of the benztropine analogues AHN-1055 and AHN-2005 using intracerebral microdialysis to evaluate brain dopamine levels and pharmacokinetic/pharmacodynamic modeling. Pharm Res. 2005 Apr;22(4):603-12.

Bauer KS, Karp JE, Garimella TS, Wu S, Tan M, Ross DD. A phase I and pharmacologic study of idarubicin, cytarabine, etoposide, and the multidrug resistance protein (MDR1/Pgp) inhibitor PSC-833 in patients with refractory leukemia. Leuk Res. 2005 Mar;29(3):263-71.

Garimella TS, Ross DD, Eiseman JL, Mondick JT, Joseph E, Nakanishi T, Bates SE, Bauer KS. Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors. Cancer Chemother Pharmacol. 2005 Feb;55(2):101-9.

Iqbal T, Kinjo M, Dowling TC. Determination of Rhodamine 123 in cell lysate by HPLC with visible wavelength detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jan 25;814(2):259-62.

Salama NN, Fasano A, Thakar M, Eddington ND. The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents. J Pharmacol Exp Ther. 2005 Jan;312(1):199-205.

Dowling TC, Arjomand M, Lin ET, Allen LV Jr, McPherson ML.Relative bioavailability of ketoprofen 20% in a poloxamer-lecithin organogel. Am J Health Syst Pharm. 2004 Dec 1;61(23):2541-4.

Takebe N, Cheng X, Wu S, Bauer K, Goloubeva OG, Fenton RG, Heyman M, Rapoport AP, Badros A, Shaughnessy J, Ross D, Meisenberg B, Tricot G. Phase I clinical trial of the inosine monophosphate dehydrogenase inhibitor mycophenolate mofetil (cellcept) in advanced multiple myeloma patients. Clin Cancer Res. 2004 Dec 15;10(24):8301-8.

Wang DJ, Dowling TC, Meadows D, Ayala T, Marshall J, Minshall S, Greenberg N, Thattassery E, Fisher ML, Rao K, Gottlieb SS. Nesiritide does not improve renal function in patients with chronic heart failure and worsening serum creatinine. Circulation. 2004 Sep 21;110(12):1620-5. Garimella TS, Ross DD, Bauer KS. Liquid chromatography method for the quantitation of the breast cancer resistance protein ABCG2 inhibitor fumitremorgin C and its chemical analogues in mouse plasma and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Aug 5;807(2):203-8.

Karyekar CS, Eddington ND, Briglia A, Gubbins PO, Dowling TC. Renal interaction between itraconazole and cimetidine. J Clin Pharmacol. 2004 Aug;44(8):919-27.

Iqbal T, Karyekar CS, Kinjo M, Ngan GC, Dowling TC. Validation of a simplified method for determination of cimetidine in human plasma and urine by liquid chromatography with ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 25;799(2):337-41.

Rudek MA, Bauer KS Jr, Lush RM 3rd, Stinson SF, Senderowicz AM, Headlee DJ, Arbuck SG, Cox MC, Murgo AJ, Sausville EA, Figg WD.Clinical pharmacology of flavopiridol following a 72-hour continuous infusion. Ann Pharmacother. 2003 Oct;37(10):1369-74.

Persky AM, Eddington ND, Derendorf H. A review of the effects of chronic exercise and physical fitness level on resting pharmacokinetics. Int J Clin Pharmacol Ther. 2003 Nov;41(11):504-16.

Raje S, Cao J, Newman AH, Gao H, Eddington ND. Evaluation of the blood-brain barrier transport, population pharmacokinetics, and brain distribution of benztropine analogs and cocaine using in vitro and in vivo techniques. J Pharmacol Exp Ther. 2003 Nov;307(2):801-8.

Dowling TC, Briglia AE, Fink JC, Hanes DS, Light PD, Stackiewicz L, Karyekar CS, Eddington ND, Weir MR, Henrich WL. Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease. Clin Pharmacol Ther. 2003 May;73(5):427-34.

Edelman MJ, Bauer K, Khanwani S, Tait N, Trepel J, Karp J, Nemieboka N, Chung EJ, Van Echo D. Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug. Cancer Chemother Pharmacol. 2003 May;51(5):439-44.