An agenda for the Metallotherapeutics Research Center's first Mid-Atlantic Symposium, "Frontiers in Metals in Medicine," is provided below for the convenience of symposium attendees.

The symposium is scheduled for Friday, Nov. 15, 2019, from 9 a.m. to 5 p.m. at the University of Maryland School of Pharmacy, located at 20 N. Pine Street in Baltimore, Md.

TimeActivity
8:30-9 a.m. Welcome Breakfast
Coffee, pastries, and bagels
9-9:15 a.m. Introduction to the Mission and Goals of the Metallotherapeutics Research Center

Angela Wilks, PhD
Isaac E. Emerson Professor & Program Chair in Chemical and Biological Discovery
Department of Pharmaceutical Sciences
University of Maryland School of Pharmacy

Sarah Michel, PhD
Professor and Associate Dean for Graduate Programs
Department of Pharmaceutical Sciences
University of Maryland School of Pharmacy
Session I: Identification and Characterization of Metallotherapeutic Targets
Session Chair: Susana Mouriño (University of Maryland, Baltimore)
9:15-9:40 a.m. Characterization of the Ferrous Iron Transport Protein FeoC
Aaron T. Smith, PhD
Assistant Professor
Department of Chemistry and Biochemistry
University of Maryland, Baltimore County
9:40-10:05 a.m. Iron Transport at the Mitochondrial Membrane and at the Host Pathogen Interface of Legionella pneumophila: A Tale of Two Transporters
Anirban Banerjee, PhD
Investigator
National Institute of Child Health and Human Development
10:05-10:30 a.m. Metals and ROS: Tales from a Successful Fungal Pathogen
Valeria Culotta, PhD
Professor
Department of Biochemistry and Molecular Biology
Johns Hopkins University School of Medicine
10:30-10:40 a.m. Flash Talk Selected from Poster Abstracts
10:40-11 a.m. Coffee Break
Session II: Synthesis of Metal Based Inhibitors
Session Chair: Iqbal Hamza (University of Maryland, College Park)
11-11:25 a.m. Anti-Virulence by Targeting the Pseudomonas aeruginosa Heme Oxygenase (HemO)
Fengtian Xue, PhD
Associate Professor
Department of Pharmaceutical Sciences
University of Maryland School of Pharmacy
11:25-11:50 a.m. Brain-Prevalent Metals Influence the Conformational Profile of Alpha-Synuclein Assemblies
Heather R. Lucas, PhD
Assistant Professor of Chemistry
Virginia Commonwealth University
11:50 a.m. - 12:15 p.m. Enhancing Fragment-Based Drug Discovery with Metallofragments
Seth Cohen, PhD
Professor
Department of Chemistry and Biochemistry
University of California, San Diego
12:15-12:25 p.m. Flash Talk Selected from Poster Abstracts
12:30-2 p.m. Lunch and Poster Session
Session III: Metals and Disease
Session Chair: Amanda Oglesby-Sherrouse (University of Maryland School of Pharmacy)
2-2:25 p.m. Mischief Managed: Chaperoning Iron in the Cells and Tissues of Mammals
Caroline Philpott, MD
Section Chief, Genetics and Metabolism Section
Liver Diseases Branch
National Institute of Diabetes and Digestive and Kidney Diseases
2:25-2:50 p.m. New Regulatory Mechanisms Directing Adaptation to Cu Stress in the Opportunistic Pathogen Cryptococcus neoformans
Aaron D. Smith, PhD
Postdoctoral Fellow
Duke University School of Medicine
2:50-3:15 p.m. Copper Homeostasis and the Processing of Dietary Fat in Intestine
Svetlana Lutsenko, PhD
Professor of Physiology
Johns Hopkins University School of Medicine
3:15-3:25 p.m. Flash Talk Selected from the Posters
3:25-3:45 p.m. Coffee Break
Session IV: Emerging Tools and Technologies in Metallotherapeutics
Session Chair: Maureen Kane (University of Maryland School of Pharmacy)
3:45-4:10 p.m. Translational Bioinorganic Chemistry: Applying LC-ICP-MS to Track Iron Nanoparticles in a Clinical Trial
Sarah Michel, PhD
Professor and Associate Dean for Graduate Programs
Department of Pharmaceutical Sciences
University of Maryland School of Pharmacy
4:10-4:35 p.m. New Tools for Studying Cellular Metal Ion Transport
Richard N. Thompson, PhD
Associate Professor of Biochemistry and Molecular Biology
University of Maryland School of Medicine
4:35-5 p.m. Uncovering Targetable Conformers of the Cytoplasmic Heme Binding Protein PhuS from P. aeruginosa Using HDX-MS and In-Silico Ensemble Refinement
Daniel Deredge, PhD
Assistant Professor
University of Maryland School of Pharmacy
5-6:30 p.m. Wine and Cheese Social