PHAR610: Pharmaceutical Formulation and Unit Processes (2-4 Credits)
This course addresses the rational design and formulation of dosage forms, and the processes and equipment in their large scale manufacture. Consideration is on how the interplay of formulation and process variables affects both the manufacturability of the dosage form and its performance as a drug delivery system.
PHAR621: Molecular Biophysics (1-3 Credits)
This course focuses on physical aspects of the structure and function paradigm of biological and pharmaceutical molecules. It is designed for both experimentally and theoretically/computationally oriented graduate students in pharmaceutical, chemical, biochemical and medical sciences. This course offers student’s exposure to basic theories and computational methods for studying the mechanisms of biological systems at an atomic level of detail.
PHAR622: Advanced Pharmacogenomics (1 Credit)
Interindividual variability in drug effects and the lack of reliable prediction of this variability have been recognized as major barriers to safe and efficient therapeutics. Genetic makeup is one of the intricate factors that has substantial influence on drug efficacy or toxicity. Pharmacogenomics deals with hereditary and effects on drug response. It combines traditional pharmaceutical sciences with contemporary knowledge of genes, proteins and SNPs. The objective of this course is to enable the student to understand basic pharmacogenomic principles, and their potential use for developing better and safer drugs.
PHAR651: Recent Advances in Pharmacology (1 Credit)
Provides students with an understanding of the recent progress in basic and clinical pharmacology research, from new concepts in pharmacology to the new techniques and trends in pharmacology.
PHAR667: Organic Synthesis in Drug Design (1-2 Credits)
Students are taught the application of synthetic organic chemistry to drug design. The course includes instruction in a range of standard functional group transformations and chemical mechanisms. Discussion then shifts to apply this synthetic chemistry knowledge to the synthesis of peptides, peptoids, small-molecules and natural products. Protecting group chemistry as well as solid phase synthesis are also discussed.
PHAR707: Drug Transport and Metabolism (3 Credits)
This course will provide basic knowledge about drug absorption at different sites in the human body (e.g., intestine, blood-brain barrier, kidney, liver) and the physicochemical and pharmaceutical factors, as well as pathophysiologic conditions, that influence drug penetration. This course will allow the students to understand the choice of a particular absorption route and dosage form. Furthermore, the interplay of drug metabolism and drug transport will be discussed.
PHAR751: Drug Design (3 Credits)
Applications of chemical and biological principles to the rational design of drugs. Topics include targets of biologically active molecules, approaches to studying ligand and target interactions, overview of drug discovery, agents acting on specific targets, combinatorial chemistry, computation chemistry, and structure activity relationships.
PHAR755: Topics in Metallobiochemistry (2 Credits)
This course introduces basic concepts pertaining to metal ions in biological systems. Topics include metal ions in proteins, cofactors and metal clusters, metal ion transport and storage and regulation, and metalloenzymes. There is a series of two hour lectures on specific topics followed by student presentations of recent research articles from the literature on said specific topics. Students are graded on their paper selection, presentation, analysis of the paper, and intellectual contribution. Pre-requisites: PHAR 600/601.
